Welcome to the pfizer inflammation & immunology pipeline

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dermatology
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DISEASE
STATE

DERMATOLOGY1,a

PHASE 1

PHASE 3

JAK1e

INHIBITOR

RECRUITING

PDE4g

INHIBITOR

RECRUITING

DISCOVER OUR PIPELINE COMPOUNDS

Explore the compounds currently under
investigation

KEY DERMATOLOGY COMPOUNDS 1,a

Ritlecitinib (PF-06651600)

Dermatology disease states under investigation:2-5

Alopecia areata and vitiligo

Crisaborole
PDE4

Inhibitor

Dermatology disease states under investigation:6,7

Atopic dermatitis and stasis dermatitis

Abrocitinib (PF-04965842)
JAK1

Inhibitor

Dermatology disease states under investigation:8,9

Atopic dermatitis

Brepocitinib (PF-06700841)

Dermatology disease states under investigation:4,5,10-12

Alopecia areata, atopic dermatitis, hidradenitis suppurativa, plaque psoriasis, and vitiligo

PF-06826647

Dermatology disease states under investigation:12,13

Hidradenitis suppurativa and plaque psoriasis

PF-06650833

Dermatology disease states under investigation:12

Hidradenitis suppurativa

ONGOING CLINICAL TRIALS

Investigate the latest therapies with
ongoing clinical trials

SEE THE LATEST DEVELOPMENTS IN OUR PHASE 3 TRIALS

Phase 3:

Abrocitinib is an investigational JAK1 inhibitor
for atopic dermatitis (JADE EXTEND)

Phase 3:

Crisaborole is a topical PDE4 inhibitor under
investigation for once daily use in atopic dermatitis

Phase 3:

Ritlecitinib is an investigational oral JAK3/TEC
inhibitor for alopecia areata

Phase 2b/3:

Ritlecitinib is an investigational oral JAK3/TEC
inhibitor for alopecia areata

LEARN MORE ABOUT OUR OTHER ONGOING TRIALS

Phase 3:

Brepocitinib is an investigational topical
TYK2/JAK1 inhibitor for plaque psoriasis

Phase 2b:

Brepocitinib is an investigational topical
TYK2/JAK1 inhibitor for atopic dermatitis

Phase 2b:

PF-06650833 is an investigational oral IRAK4
inhibitor,
PF-06826647 is an investigational oral TYK2
inhibitor, and
Brepocitinib is an investigational oral
TYK2/JAK1 inhibitor for hidradenitis suppurativa

Phase 2b:

PF-06826647 is an investigational oral TYK2
inhibitor for plaque psoriasis

gastroenterology
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DISEASE
STATE

GASTROENTEROLOGY1,a

PHASE 1

DGAT2

INHIBITOR

COMPLETED

PHASE 3

DISCOVER OUR PIPELINE COMPOUNDS

Explore the compounds currently under
investigation

KEY GASTROENTEROLOGY COMPOUNDS1,a

Ritlecitinib (PF-06651600)

Dermatology disease states under investigation:2-5

Alopecia areata and vitiligo

Brepocitinib (PF-06700841)

Dermatology disease states under investigation:2,3

Crohn’s disease and ulcerative colitis

Dekavil (PF-06480605; F8-IL 10)

Gastroenterology disease states under investigation:4

Ulcerative colitis

PF-06480605

Gastroenterology disease states under investigation:5

Ulcerative colitis

PF-06826647

Gastroenterology disease states under investigation:6

Ulcerative colitis

ONGOING CLINICAL TRIALS

Investigate the latest therapies with
ongoing clinical trials

Phase 2b:

Brepocitinib is an investigational oral
TYK2/JAK1 inhibitor and ritlecitinib is an
investigational oral JAK3/TEC inhibitor for
ulcerative colitis

Phase 2b:

PF-06480605 is an investigational TNFSF15
blocker for ulcerative colitis

Phase 2b:

PF-06826647 is an investigational TYK2
inhibitor for ulcerative colitis

Phase 2a:

Brepocitinib is an investigational oral
TYK2/JAK1 inhibitor and ritlecitinib is an
Investigatetional oral JAK3/TEC inhibitor for
Crohn's disease

Phase 2a:

Dekavil is an investigational IL-10
immunocytokine for ulcerative colitis

rheumatology
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DISEASE
STATE

RHEUMATOLOGY1,a

PHASE 1

Chemokine

INHIBITOR

RECRUITING

PHASE 3

JAK1/
JAK3

INHIBITOR

RECRUITING

JAK1/
JAK3d

INHIBITOR

RECRUITING

DISCOVER OUR PIPELINE COMPOUNDS

Explore the compounds currently under
investigation

KEY RHEUMATOLOGY COMPOUNDS1,a

Tofacitinib
JAK1/
JAK3

Inhibitor

Rheumatology disease states under investigation:2,3

Juvenile idiopathic arthritis and systemic juvenile idiopathic arthritis

Brepocitinib (PF-06700841)

Rheumatology disease states under investigation:4,5

Lupus and psoriatic arthritis

Dekavil (PF-06480605; F8-IL 10)

Rheumatology disease states under investigation:6

Rheumatoid arthritis

PF-06650833

Rheumatology disease states under investigation:7

Rheumatoid arthritis

Ritlecitinib (PF-06651600)

Rheumatology disease states under investigation:8

Rheumatoid arthritis

ONGOING CLINICAL TRIALS

Investigate the latest therapies with
ongoing clinical trials

SEE THE LATEST DEVELOPMENTS IN OUR PHASE 3 TRIALS

Phase 3:

Tofacitinib is a JAK1/JAK3 inhibitor under
investigation for systemic juvenile idiopathic arthritis

Phase 2/3:

Tofacitinib is a JAK1/JAK3 inhibitor under
investigation for juvenile idiopathic arthritis

LEARN MORE ABOUT OUR OTHER ONGOING TRIALS

Phase 2b:

Brepocitinib is an investigational oral TYK2/JAK1 inhibitor for lupus

Phase 1:

PF-06835375 in an investigational chemokine
inhibitor for lupus

ADVANCING RESEARCH WITH THE GOAL OF LIFE-CHANGING IMPACT

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