IL-10 Pathway

IL-10 is an anti-inflammatory cytokine that may help reduce inflammation in multiple diseases, such as rheumatoid arthritis and ulcerative colitis.1,2

IL-10 Pathway 3

Figure adapted from Fioranelli M, Grazia RM. J lntegr Cardiol. 2014;1(1):2-6.

  • Anti-inflammatory cytokines, such as IL-10, may help prevent inflammatory and autoimmune conditions4
  • The binding of IL-10 to its receptor triggers a signaling pathway that ultimately limits the production of proinflammatory cytokines and chemokines, such as IL-1, IL-6, and TNF-α3-5
  • IL-10 plays a potential role in human diseases:
    • In rheumatoid arthritis, the addition of IL-10 to synovial membrane cultures can decrease IL-1β and TNF-α expression. Similarly, blocking endogenous IL-10 can cause a 2- to 3-fold increase in the expression of these proinflammatory cytokines6
    • In ulcerative colitis, the IL-10 gene has been identified as a susceptibility locus, with certain genetic variants being associated with the disease7
  • Activating the IL-10 pathway has shown potential as a therapeutic strategy in preclinical mouse models1-8


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