Figure adapted from Fioranelli M, Grazia RM. J lntegr Cardiol. 2014;1(1):2-6.
- Anti-inflammatory cytokines, such as IL-10, may help prevent inflammatory and autoimmune conditions4
- The binding of IL-10 to its receptor triggers a signaling pathway that ultimately limits the production of proinflammatory cytokines and chemokines, such as IL-1, IL-6, and TNF-α3-5
- IL-10 plays a potential role in human diseases:
- – In rheumatoid arthritis, the addition of IL-10 to synovial membrane cultures can decrease IL-1β and TNF-α expression. Similarly, blocking endogenous IL-10 can cause a 2- to 3-fold increase in the expression of these proinflammatory cytokines6
- – In ulcerative colitis, the IL-10 gene has been identified as a susceptibility locus, with certain genetic variants being associated with the disease7
- Activating the IL-10 pathway has shown potential as a therapeutic strategy in preclinical mouse models1-8