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Figure adapted from Paller AS et al. J Allergy Clin Immunol. 2017;140(3):633-643.

  • Chronic idiopathic inflammatory diseases of the skin and gut are characterized by a hyperactive immune milieu containing upregulated chemokines, proinflammatory cytokines, and infiltration of an assortment of innate and adaptive immune cells1,8-111
  • The Janus kinase-signal transducer and activator of transcription (JAK-STAT) is a signaling pathway by which a number of proinflammatory cytokines (eg, interleukin [IL]-4, IL-13) may transduce their pathophysiologic functions and contribute to immune hyperactivity1,8
  • The binding of a cytokine to its receptor leads to JAK activation, which in turn phosphorylates STATs. STATs then dimerize and translocate to the nucleus, where they may direct expression of a number of genes affecting differentiation of immune cells and lead to upregulated cytokines1,8