TEC PATHWAYs

Inhibition of TEC family of non-receptor tyrosine kinases may have implications for conditions such as alopecia areata, Crohn’s disease, rheumatoid arthritis, ulcerative colitis, and vitiligo. 1,2

TEC PATHWAYS
  • The TEC family of non-receptor kinases is composed of 5 proteins, BTK, BMX, ITK, RLK, and TEC, which are mostly expressed in hematopoietic cells1,3
  • BTK and ITK are the most well-defined TEC kinases and are activated downstream of the B cell receptor (BCR) and T cell receptor (TCR), respectively2,3
  • Once phosphorylated, active BTK and ITK can promote the production of second messengers via PLC-γ activation2,3
  • Inhibiting these pathways may have an important role in regulating the inflammatory response in human diseases1,2

ADVANCING RESEARCH WITH THE GOAL OF LIFE-CHANGING IMPACT

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