TEC PATHWAY

The TEC pathway plays an important role in regulating the inflammatory response. Inhibiting these pathways may have implications for conditions such as alopecia areata, Crohn’s disease, rheumatoid arthritis, ulcerative colitis, and vitiligo. 1,2

TEC PATHWAY
  • The TEC family of non-receptor kinases is composed of 5 proteins, BTK, BMX, ITK, RLK, and TEC, which are mostly expressed in hematopoietic cells1,3
  • BTK and ITK are the most well-defined TEC kinases and are activated downstream of the B cell receptor (BCR) and T cell receptor (TCR), respectively2,3
  • Once phosphorylated, active BTK and ITK can promote the production of second messengers via PLC-γ activation2,3
  • Inhibiting these pathways may have an important role in regulating the inflammatory response in human diseases1,2

BMX=bone marrow tyrosine kinase on chromosome X; BTK=Bruton’s tyrosine kinase; ITK=interleukin 2-inducible T cell kinase; PLC=phospholipase C; RLK=resting lymphocyte kinase; TEC=tyrosine kinase expressed in hepatocellular carcinoma.

References: 1. Xu H, et al. ACS Chem Biol. 2019;14(6):1235-1242. 2. Horwood NJ, et al. Int Rev lmmunol. 2012;31(2):87-103. 3. Andreotti AH, et al. Cold Spring Harb Perspect Biol. 2010;2(7):a002287.

ADVANCING RESEARCH WITH THE GOAL OF LIFE-CHANGING IMPACT

Are you a healthcare professional?

The information on this site is intended for U.S. healthcare professionals.

Yes No
Learn more about our investigational compounds under development for dermatology, gastroenterology, and rheumatology
Breakthroughs that change patients' lives