TEC PATHWAYs

Inhibition of TEC family of non-receptor tyrosine kinases may have implications for conditions such as alopecia areata, Crohn’s disease, rheumatoid arthritis, ulcerative colitis, and vitiligo. ^1,2

TEC PATHWAYS

The TEC family of non-receptor kinases is composed of 5 proteins, BTK, BMX, ITK, RLK, and TEC, which are mostly expressed in hematopoietic cells^1,3
BTK and ITK are the most well-defined TEC kinases and are activated downstream of the B cell receptor (BCR) and T cell receptor (TCR), respectively^2,3
Once phosphorylated, active BTK and ITK can promote the production of second messengers via PLC-γ activation^2,3
Inhibiting these pathways may have an important role in regulating the inflammatory response in human diseases^1,2

BMX=bone marrow tyrosine kinase on chromosome X; BTK=Bruton’s tyrosine kinase; ITK=interleukin 2-inducible T cell kinase; PLC=phospholipase C; RLK=resting lymphocyte kinase; TEC=tyrosine kinase expressed in hepatocellular carcinoma.

References: 1. Xu H, et al. ACS Chem Biol. 2019;14(6):1235-1242. 2. Horwood NJ, et al. Int Rev lmmunol. 2012;31(2):87-103. 3. Andreotti AH, et al. Cold Spring Harb Perspect Biol. 2010;2(7):a002287.

TEC PATHWAYs

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