
- The TEC family of non-receptor kinases is composed of 5 proteins, BTK, BMX, ITK, RLK, and TEC, which are mostly expressed in hematopoietic cells1,3
- BTK and ITK are the most well-defined TEC kinases and are activated downstream of the B cell receptor (BCR) and T cell receptor (TCR), respectively2,3
- Once phosphorylated, active BTK and ITK can promote the production of second messengers via PLC-γ activation2,3
- Inhibiting these pathways may have an important role in regulating the inflammatory response in human diseases1,2