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TEC PATHWAY

The TEC pathway plays an important role in regulating the inflammatory response. Inhibiting these pathways may have implications for conditions such as alopecia areata, Crohn’s disease, rheumatoid arthritis, ulcerative colitis, and vitiligo. 1,2

TEC PATHWAY
  • The TEC family of non-receptor kinases is composed of 5 proteins, BTK, BMX, ITK, RLK, and TEC, which are mostly expressed in hematopoietic cells1,3
  • BTK and ITK are the most well-defined TEC kinases and are activated downstream of the B cell receptor (BCR) and T cell receptor (TCR), respectively2,3
  • Once phosphorylated, active BTK and ITK can promote the production of second messengers via PLC-γ activation2,3
  • Inhibiting these pathways may have an important role in regulating the inflammatory response in human diseases1,2

ADVANCING RESEARCH WITH THE GOAL OF LIFE-CHANGING IMPACT

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