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Figure adapted from Richard AC et al. J Leukoc Biol. 2015;98(3):333-345.

  • Members of the tumor necrosis factor (TNF) superfamily are contributors to important immune functions, including inflammation, cell death, homeostasis, host defense, and autoimmunity4
  • The TNF superfamily member 15 (TNFSF15) is a cytokine whose expression is locally induced by proinflammatory stimuli2
  • Expression of TNFSF15 has been shown to be upregulated and localized to specific intestinal tissues in subjects with inflammatory bowel disease2
  • TNFSF15 may potentially contribute to inflammatory bowel disease pathology through:
    • Increasing the production of additional proinflammatory cytokines5
    • Mediating mucosal hyperplasia1,6
    • Promoting intestinal fibrosis7,8
  • Genetic variants of TNFSF15 have been associated with the development of or susceptibility to autoimmune and inflammatory diseases in certain ethnic populations9-14