TNFSF15 Pathway

The TNF superfamily member ligand TNFSF15, also known as TL1a, is associated with the expression of proinflammatory cytokines. Increased levels of TNFSF15 have also been found at the site of inflammation in inflammatory bowel disease. Therefore, inhibition of TNFSF15 may be an option for this condition.1,2

TNFSF15 PATHWAY 3

Figure adapted from Richard AC et al. J Leukoc Biol. 2015;98(3):333-345.

  • Members of the tumor necrosis factor (TNF) superfamily are contributors to important immune functions, including inflammation, cell death, homeostasis, host defense, and autoimmunity4
  • The TNF superfamily member 15 (TNFSF15) is a cytokine whose expression is locally induced by proinflammatory stimuli1,2
  • Expression of TNFSF15 has been shown to be upregulated and localized to specific intestinal tissues in subjects with inflammatory bowel disease2
  • TNFSF15 may potentially contribute to inflammatory bowel disease pathology through:
    • Increasing the production of additional proinflammatory cytokines5
    • Mediating mucosal hyperplasia1,6
    • Promoting intestinal fibrosis7,8
  • Genetic variants of TNFSF15 have been associated with the development of or susceptibility to autoimmune and inflammatory diseases in certain ethnic populations9-14

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