JAK PATHWAY

JAK inhibition may be a factor in a number of inflammatory diseases, including alopecia areata, atopic dermatitis, Crohn's disease, non-segmental vitiligo, plaque psoriasis, psoriatic arthritis, rheumatoid arthritis, systemic lupus erythematosus, and ulcerative colitis.1-7,12-15

Janus kinase (JAK) inhibition may be a factor in a number of inflammatory diseases, including alopecia areata, atopic dermatitis, Crohn's disease, non-segmental vitiligo, plaque psoriasis, psoriatic arthritis, rheumatoid arthritis, systemic lupus erythematosus, and ulcerative colitis.1-9,17,18

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IRAK4 PATHWAY

IRAK4 plays an important role in innate immunity. Inhibiting IRAK4 kinase activity may have implications for chronic inflammatory diseases such as rheumatoid arthritis.1-5

IRAK4 plays an important role in innate immunity. Inhibiting IRAK4 kinase activity may have implications for chronic inflammatory diseases such as rheumatoid arthritis.10-14

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TNFSF15 Pathway

The TNF superfamily member ligand TNFSF15 is associated with the expression of proinflammatory cytokines. Increased levels of TNFSF15 have also been found at the site of inflammation in inflammatory bowel disease (IBD). Therefore, inhibition of TNFSF15 may be an option for this condition.1,2

The TNF superfamily member ligand TNFSF15 is associated with the expression of proinflammatory cytokines. Increased levels of TNFSF15 have also been found at the site of inflammation in inflammatory bowel disease. Therefore, inhibition of TNFSF15 may be an option for this condition.15,16

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IL-10 Pathway

IL-10 is an anti-inflammatory cytokine that may help reduce inflammation in multiple diseases, such as rheumatoid arthritis and ulcerative colitis.1,2

Interleukin IL-10 is an anti-inflammatory cytokine that may help reduce inflammation in multiple diseases, such as rheumatoid arthritis and ulcerative colitis.17-18

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